Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.

Online data supplement Oxidized Phospholipids Induce Type VIII Collagen Expression and Vascular Smooth Muscle Cell Migration. Short title: OxPLs induce type VIII collagen expression in VSMC

Inflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells

The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...

"Obese" smooth muscle cells fail to assemble collagen fibrils.

Smooth muscle cells (SMCs) play an important role in the stabilization of atherosclerotic plaques. They contribute to form a firm fibrous cap by synthesizing and assembling fibrillar collagen I, a process that requires the synthesis of fibronectin and activation of integrins. However, extracellular matrix composition changes during the formation of atherosclerotic plaques. Type I and III collag...

Migration and growth are attenuated in vascular smooth muscle cells with type VIII collagen-null alleles.

OBJECTIVE Type VIII collagen is upregulated after vascular injury and in atherosclerosis. However, the role of type VIII collagen endogenously expressed by smooth muscle cells (SMCs) and in the context of the vascular matrix microenvironment, which is rich in type I collagen, is not known. To address this, we have compared aortic SMCs from wild-type (WT) mice to SMCs from type VIII collagen-def...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) modulates the expression of type VIII collagen mRNA in vascular smooth muscle cells and both are codistributed during atherogenesis.

The expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and type VIII collagen was studied in human arteries. GM-CSF and type VIII collagen were codistributed in all layers of the walls of nondiseased arteries and during early atherogenesis with up to type V lesions. The number of cells expressing both mRNAs increased during the development of advanced atherosclerotic lesion...